From single-herb phytochemically characterized powders to multi-phase microencapsulated systems, explore our commercial research and contract supply modules.
Cell-level metabolic screening, targeted receptor binding, and bioactivity verification in Caco-2 and HepG2 lines prior to encapsulation scale-up.
Explore In Vitro Assays
Comprehensive acute, sub-chronic toxicity, and bioavailability modeling verifying capsule stomach-to-duodenal bioavailability.
Review In Vivo Services
Establishing quantified reference fingerprints, assay protocols, and dissolution profiles conforming to USP, EP, and ChP monograph requirements.
Inspect Analytical Standards
GCP-compliant human clinical trial execution for dietary supplement efficacy claims and botanical new drug applications (IND/NDA).
View Clinical Protocols
Multi-origin botanical benchmarking to identify harvest windows and regional geo-phenotypes maximizing active molecule density.
Inspect Sourcing Science
Isolation and chemical taxonomy of active alkaloids, flavonoids, and glycosides engineered for encapsulation stability and shelf longevity.
Access Screening Library
Automated high-speed tamping pin filling of size #00, #0, #1, #2 capsules with certified vegetarian HPMC, pullulan, or pharmaceutical gelatin.
Explore Capsule Manufacturing
Standardized dense botanical granulates designed with low hygroscopicity and optimal tap density for high-speed industrial encapsulation lines.
Request Technical SpecsEvaluating shifting consumer preferences, vegetarian polymer innovation, and the migration from simple toll encapsulation to integrated scientific CDMO partnerships.
Global demand has shifted decisively toward hydroxypropyl methylcellulose (HPMC) and pullulan capsules. Driven by Non-GMO, Halal, Kosher, and vegan certifications in North America and Western Europe, plant-origin polymer shells now account for over 58% of new nutraceutical formulation requests, eliminating cross-linking risks inherent to bovine and porcine gelatin.
Standard pharmaceutical gelatin contains 13%–16% equilibrium moisture, which frequently triggers hydrolysis and degradation of hygroscopic plant extracts (such as polyphenols, berberine, and standardized ginsenosides). High-performance HPMC shells provide exceptional chemical inertness and low equilibrium moisture, preserving active ingredient potency throughout 36-month shelf lifespans.
Global regulatory agencies, including US FDA (21 CFR Part 111 & Part 211), the European Medicines Agency (EMA), and the Australian TGA, have raised standards for heavy metals (lead, arsenic, cadmium, mercury via ICP-MS), pesticide residue limits (USP <561>), and ethylene oxide (EtO) residuals. Modern buyers require suppliers to provide fully auditable validation data.
| Polymer Shell Type | Base Composition | Moisture Range (%) | Oxygen Permeability | Ideal Application Scenario | Global Regulatory Compliance |
|---|---|---|---|---|---|
| Second-Gen HPMC | Pure Hydroxypropyl Methylcellulose | 4.5% – 6.5% | Moderate | Hygroscopic herbal extracts, probiotics, polyphenols | USP / EP / JP / ChP |
| Pharmaceutical Gelatin | Bovine / Porcine Bone & Hide Collagen | 13.0% – 16.0% | Very Low | Standard non-hygroscopic vitamins, minerals, lipids | USP / EP / ChP |
| Fermented Pullulan | Natural Tapioca starch fermentation | 10.0% – 13.0% | Ultra-Low (Barrier) | Oxygen-sensitive phytomedicines, premium clean-label | Non-GMO / Organic Certified |
| Enteric HPMC / Coating | HPMCP / Cellulosic Phthalates / Acrylics | 5.0% – 7.5% | Moderate | Gastric-irritant drugs, intestinal targeted release | ICH Q1A / FDA DMF |
Engineered delivery forms tailored to gastrointestinal transit dynamics, active bio-availability, and international retail channel demands.
Standardizing fine herbal powders into free-flowing granules via roller compaction or fluid bed granulation. Designed specifically for high-speed size #00 and #0 encapsulation lines without sticking, capping, or weight variance (<1.5% RSD).
Clinical-grade encapsulation of high-potency Traditional Chinese Medicine (TCM) active fractions (e.g., purified andrographolide, artemisinin derivatives, salidroside). Supported by complete chemistry, manufacturing, and control (CMC) documentation.
Synergistic blending of botanical polyphenols with astaxanthin, glutathione, and marine peptides. Employing nitrogen-flushing encapsulation chambers to inhibit oxygen exposure and preserve delicate redox antioxidants.
Protecting acid-labile bioactives or probiotics through enteric hard shell encapsulation or polymer micro-coating that withstands 0.1M HCl (pH 1.2) for 120 minutes while releasing completely within 45 minutes in simulated intestinal fluid (pH 6.8).
Pioneering multi-phase encapsulation, liquid-filled hard capsules (LFHC), and computational formulation profiling to resolve complex pharmacokinetic challenges.
Replacing conventional softgels with hermetically banded two-piece HPMC or gelatin capsules loaded with lipidic formulations, botanical self-emulsifying drug delivery systems (SEDDS), and pure volatile oils. Eliminates plasticizers, reduces thermal degradation during manufacturing, and enables high active loading of hydrophobic compounds.
Prevents cross-contamination and plasticizer-related compound migration common in traditional softgels.
Combining multiple incompatible phytochemicals within a single capsule body. Sustained-release micro-pellets, rapid-dissolving mini-tablets, and stabilized liquid phases can be co-encapsulated. This architecture allows precise dual-phase kinetics: immediate gastric release of Phase 1 bioactives followed by timed ileal release of Phase 2 ingredients.
Maintains steady-state plasma concentrations without repetitive dosing intervals.
Deploying machine learning models trained on hundreds of thousands of research batches to predict botanical powder compressibility, hygroscopic isotherms, and excipient compatibility (PVP, microcrystalline cellulose, colloidal silica). Reduces formulation cycle times from months to weeks while eliminating pilot-scale tableting and capping failures.
Optimizes tap density, Carr's Index, and Hausner Ratio for rapid automated filling.
How regional agronomic proximity, vertical industrial clustering, and modern cGMP automation create structural cost and turnaround advantages for overseas brands.
Headquartered in Changsha, Hunan, with direct sourcing corridors across prime Chinese botanical harvesting zones (Yunnan, Sichuan, Guizhou, Heilongjiang). We eliminate multiple intermediary traders, securing traceable, single-origin raw botanicals with verified harvest timing to guarantee superior active chemical content.
Unlike standalone encapsulators that purchase commodified powders on open markets, our infrastructure seamlessly integrates solvent extraction, column chromatographic purification, spray drying, roller compaction, and cleanroom encapsulation under a single technical roof.
Equipped with high-throughput Class D (ISO 8) cleanroom encapsulation machinery, automated optical desiccant counters, aluminum-plastic blister packers, and induction-sealing packaging lines capable of outputting millions of capsules weekly at competitive unit costs.
Bridging Chinese manufacturing excellence with North American, European, and Asia-Pacific regulatory dossiers for seamless cross-border customs clearance and retail registration.
Every commercial capsule batch is supported by complete analytical Certificate of Analysis (CoA) documentation, including heavy metal quantification via ICP-MS, residual solvent screening via headspace GC, pesticide multi-residue panels (500+ compounds), and verified non-irradiation / Non-GMO statements.
Our on-site testing laboratories conduct both accelerated stability (40°C ± 2°C / 75% RH ± 5% RH for 6 months) and long-term real-time stability testing (25°C ± 2°C / 60% RH ± 5% RH up to 36 months). We validate physical capsule integrity, shell brittleness, dissolution speed, and active degradation kinetics.
Operating under an entrusted contract CDMO model, we execute legally binding Non-Disclosure Agreements (NDAs). Proprietary customer formulations, specialized excipient ratios, and custom granulation parameters are segregated in encrypted systems to safeguard your market exclusivity.
Our modern Changsha manufacturing facilities and cooperative GMP sites welcome third-party and client audits, providing comprehensive access to batch records, raw material warehousing, HVAC air-handling records, and qualification certifications.
Structured milestone deliverables guarantee complete scientific oversight from raw botanical characterization through to commercial release.
Evaluate target indication, botanical source, seasonal potency fluctuations, and identify active marker molecules.
Deliverable: Sourcing & Feasibility ReportDevelop validated HPLC, GC, and HPTLC chromatographic fingerprints and quantitative assay protocols for raw materials and fill blends.
Deliverable: Validated Methods & SpecsFormulate excipients for optimal tap density, choose between vegetarian HPMC or gelatin shells, and execute pilot test runs.
Deliverable: Formulation Master RecordExecute in vitro metabolic assays, animal model pharmacodynamics, and LD50 acute/chronic toxicity safety evaluations.
Deliverable: Preclinical Safety PackageCoordinate small-scale human nutritional trials or Phase I–IV clinical studies to substantiate structure/function marketing claims.
Deliverable: Clinical Efficacy SummaryFull-scale cGMP cleanroom capsule filling, optical inspection, blister packaging, bottling, and worldwide logistics shipping.
Deliverable: Batch Release & Export CoAOver 14+ years of rigorous R&D partnership with China's tier-1 pharmaceutical enterprises, hospitals, and natural health brands.
Tongrentang Group
CR Sanjiu
Sunflower Pharma
Livzon Pharma Group
Dihon Pharmaceutical
Golden Throat Group
Yangtzi River Pharma
Humanwell Healthcare
Luoxin Pharma Group
Zhongsheng Pharma
Apeloa Pharma
Kangmei Pharmaceutical
In-depth answers addressing formulation compatibility, shell selection, testing protocols, minimum order quantities, and custom delivery options.
Choose an individual scientific service package or partner with us for end-to-end commercial supply from discovery to shelf-ready blistered products.
Validate target cellular pathways (anti-inflammatory, antioxidant, metabolic regulation) before investing in commercial encapsulation.
Inquire In Vitro Testing
Quantifying rodent bioavailability, organ distribution, and metabolic clearance to justify formulation dosages for registration files.
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Full ICH Q2(R1) validation of chromatographic assays: linearity, precision, LOD/LOQ, accuracy, and robustness testing.
Order Method Development
Randomized, double-blind, placebo-controlled human clinical trials generating verifiable data for demanding global regulatory submissions.
Schedule Clinical Scoping
Determining exact geographic origins and harvesting periods yielding up to 3x higher active marker compound density in plant parts.
Access Potency Audits
Targeted screening of rare triterpenoids, flavonoids, and active polysaccharides for integration into custom encapsulation matrices.
Start Bioactive Discovery
Modernizing centuries-old TCM formula synergies into standardized, bioavailable hard capsule and tablet delivery platforms.
Explore Formulation Design
Turnkey contract filling of gelatin and vegetarian capsules, automated checkweighing, foil blister sealing, and exported global container supply.
Request Commercial QuoteShare your target compound, desired capsule size, monthly volume expectations, or specific analytical challenges. Our lead scientific team will formulate a tailored study or manufacturing protocol within 48 hours.
