MedGence natural medicine extraction and separation equipment

Yineng Pharma botanical active ingredient research laboratory

Herbal medicine process development and pilot manufacturing

Natural medicine CDMO production for finished dosage forms

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[ Natural Medicine CRO · CDMO ]

Natural Medicine CRO & CDMO for Evidence-Based Botanical Ingredients

Q: What does a natural medicine CRO like MedGence do?

MedGence provides end-to-end research and development for plant-derived ingredients: active ingredient screening, potency evaluation by origin and season, analytical method establishment, process studies, toxicity, in vitro, animal and clinical studies, natural formulation research and contract manufacturing of active ingredients and finished products.

Q: How is my formula and process know-how protected?

We work on an entrusted contract research and manufacturing model under non-disclosure, so your product information, formulas and process parameters are not disclosed and your competitive advantage is preserved.

MedGence (Yineng Pharma) is a contract research and development organization based in Changsha, China, dedicated to natural medicine and plant-derived active ingredients. We support pharmaceutical, nutraceutical and cosmetic companies across the full value chain — from raw-material screening to the supply of finished products.

Over 14+ years we have delivered R&D programs for more than 100 leading pharmaceutical manufacturers and hospitals, completed modern medical studies of 83 classic Traditional Chinese Medicine (TCM) formulas, developed 22 innovative natural medicines, obtained 56 hospital preparation registrations and established quality standards and production processes for nearly 400 single-herb medicines.

14+ yrsNatural medicine R&D
300+Research staff
CRO + CDMOLab to commercial batch

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[ R&D Vision ]

Turning Traditional Knowledge into Verifiable Data

“Natural medicine earns global trust only when every claim is backed by reproducible chemistry, validated methods and controlled studies. We combine classical TCM formulation experience with modern analytical and pharmacological tools, so each ingredient we deliver can be traced, quantified and defended in front of regulators and consumers.”

— MedGence Scientific Leadership Team

[ Custom R&D Consultation ]

Talk to a Scientist About Your Project

Share a target indication, botanical source or dosage form and our team will scope the right study package and timeline.

What to include in your project brief

Target effect, indication or claim you want to support
Preferred botanical(s) or active compound, if known
Product category: supplement, drug candidate or cosmetic
Desired dosage form and estimated annual volume
Destination market and regulatory requirements

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Hundreds of Thousands of Research Batches

Our accumulated database spans natural raw materials, TCM herbs and medical preparations — enabling faster screening decisions and lower development risk.

Built for Three Markets

Dietary supplements & nutraceuticals
Phytochemical new drug candidates
Cosmetic & personal-care actives

Confidential by Design

Under our entrusted research and manufacturing model, your formulas, process parameters and know-how are never disclosed — protecting your competitive advantage from the first assay to the final batch.

[ Core Capabilities 02 ]

12 Integrated Natural Medicine R&D and Manufacturing Services

01 · Discovery Screening of botanical active ingredients in plants

Botanical Active Ingredient Screening

Plants contain alkaloids, polysaccharides, saponins and many other bioactive compounds. Using our accumulated phytochemical data and analytical capacity, we identify which substances best deliver your target effect — and which plant sources contain them at the highest density — balancing cost efficiency with environmental sustainability.

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02 · Sourcing Science Potency evaluation of botanical actives by origin and harvest season

Potency Evaluation by Origin, Season & Plant Part

The same species can vary widely in active-ingredient potency depending on growing region, harvest season and the plant part used. We quantify these differences so you can lock in the optimal origin, harvest window and plant part, building a high-yield, cost-effective sourcing strategy.

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03 · Analytics HPLC and HPTLC analytical method establishment for active ingredients

Analytical Method Establishment

A validated test method is the foundation of quality control and market trust. We develop identification and assay methods using HPTLC, HPLC, GC and chromatographic fingerprinting, giving your QC team reliable tools to confirm identity, content and batch-to-batch consistency.

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04 · Process Manufacturing process study for botanical active ingredients

Process Study for Active Ingredients

Once a target ingredient is confirmed, production economics decide competitiveness. We optimize raw-material pretreatment, extraction, purification and drying — the critical parameters that determine yield, purity and scale-up success — while reducing pressure on natural resources.

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05 · Formulation Process Manufacturing process study for finished natural products

Process Study for Finished Products

Turning actives into consumer products can cause content loss, poor solubility or unpleasant taste. Our process scientists resolve these formulation challenges so the finished product retains its active content and delivers the expected user experience.

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06 · Safety Toxicity studies including LD50 acute chronic and genotoxicity

Toxicity Studies (LD50, Acute, Chronic, Genotoxicity)

Safety must be proven before a product reaches the market. We perform acute toxicity (LD50), chronic toxicity and genetic toxicity studies, giving you the evidence to launch effective, safe products with confidence.

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07 · Efficacy Screening In vitro test of natural active ingredients on cells

In Vitro Testing

Cell- and organ-level assays reveal how tissues respond to an active ingredient at a fraction of the time and cost of in vivo work. In vitro data is especially valuable for go/no-go decisions in programs such as blood-glucose management or antiviral development.

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08 · Preclinical Animal study for efficacy and safety of natural products

Animal Studies

Toxicity and efficacy studies in animal models provide fast, affordable evidence that a product is effective and harmless — a particularly meaningful reference for dietary supplements and cosmetics before human testing.

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09 · Clinical Clinical study Phase I to Phase IV for natural medicines

Clinical Studies (Phase I–IV)

For new actives or formulas developed under contract research, we arrange small-group human trials for dietary supplements as well as Phase I, II, III and IV clinical studies required for a new drug application (NDA).

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10 · Formulation Natural herbal formulation research service

Natural Formulation Research

Drawing on deep TCM research experience, we design natural formulations that enhance supplement efficacy or form the basis of new medicines — covering formula design, raw-material standards, analytical methods, process improvement, efficacy and toxicity studies, as a full package or as individual tasks.

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11 · CDMO

Contract manufacturing OEM for botanical active ingredients

Contract Manufacturing (OEM) for Active Ingredients

Our own pilot plant and partner factories, directly managed by our technical team, transfer study results smoothly into production. Actives are supplied as concentrated liquids, powders, pastes or volatile oils — with your product information kept strictly confidential.

Request specifications

12 · CDMO

CDMO contract manufacturing for finished herbal products

Contract Manufacturing (OEM/CDMO) for Finished Products

Full contract development and manufacturing for oral liquids, capsules, softgels, tablets, soluble powders and granules — backed by our technical expertise to guarantee timely delivery, reliable quality and non-disclosure of your know-how.

Request specifications

[ End-to-End Workflow 03 ]

From Raw Herb to Registered Product: How Your Project Moves Forward

Engage us for a single study or the complete chain. Every stage ends with a defined deliverable, so procurement and R&D teams always know what they receive.

01
Screen & Source
Identify the most effective compounds and the plant origin, season and part with the highest content.
Deliverable: target & sourcing report
02
Standardize & Analyze
Build HPTLC, HPLC, GC and fingerprint methods plus raw-material quality standards.
Deliverable: validated methods & specs
03
Optimize the Process
Define pretreatment, extraction, purification, drying and dosage-form parameters for scale-up.
Deliverable: key process parameters
04
Prove Safety & Efficacy
Run in vitro assays, animal models and LD50, acute, chronic and genotoxicity studies.
Deliverable: preclinical data package
05
Clinical Validation
Small-group human trials for supplements or Phase I–IV studies supporting an NDA.
Deliverable: clinical study data
06
Manufacture & Supply
Pilot and commercial OEM/CDMO production with confidential, timely delivery.
Deliverable: commercial batches

[ Data & Scale 04 ]

Proven Scale in Natural Medicine Research

Verifiable track record built with China’s leading pharmaceutical groups, TCM hospitals and research universities.

Years of natural medicine R&D

Research staff & scientists

Pharma manufacturers & hospitals served

Innovative projects developed

Classic TCM formulas modernized

Innovative natural medicines developed

Hospital preparation registrations

Single-herb standards & processes established

[ Applications 05 ]

Applications & Deliverable Formats for Global Brands

Whether you are reformulating a supplement or advancing a phytochemical drug candidate, we match study design and dosage form to your market.

Dietary Supplements & Nutraceuticals

Potency-standardized extracts, evidence-backed botanical formulas and small-group human trials that help substantiate product efficacy for demanding retail and e-commerce channels.

Phytochemical New Drug Development

From active-compound screening to NDA-supporting Phase I–IV data, built on the experience of 22 innovative natural medicines already developed by our team.

Cosmetics & Personal Care

New plant-derived actives supported by in vitro and animal safety and efficacy data, giving formulators clean-label ingredients with documented performance.

Active Ingredient Forms

Concentrated liquidsExtract powdersPastesVolatile oilsSingle-herb extracts

Finished Dosage Forms

Oral liquidsCapsulesSoftgelsTabletsSoluble powdersGranules

[ Clients & Partners 06 ]

Trusted by Leading Pharmaceutical Groups and TCM Hospitals

Our R&D work supports many of China’s most established pharmaceutical manufacturers, university hospitals and TCM institutions.

China Beijing Tongrentang Group

China Resources Sanjiu Medical & Pharmaceutical

Sunflower Pharmaceutical Group

Livzon Pharmaceutical Group

Dihon Pharmaceutical Group

Golden Throat Holdings Group

Yangtzi River Pharmaceutical Group

Beihai Gofar Chuanshan Biological

Humanwell Healthcare Group

SCIMYTH Pharmaceutical Group

Shandong Hanfang Pharmaceutical

Luoxin Pharmaceutical Group

Guangdong Zhongsheng Pharmaceutical

Hunan Brilliance & Abundance Scientific Chinese Herbal Medicine

Apeloa Pharmaceutical

Hunan Heng Chang Pharmaceutical Group

Baotou Traditional Chinese Medicine

Kamp Medicine

Guangxi Santo Pharmaceutical

Hunan Kangshou Pharmaceutical

Jiangxi Juwang Pharmaceutical Industry

Beijing Tcmages Pharmaceutical

Guizhou Ruihe Pharmaceutical

Anhui CR Jinchan Pharmaceutical

Kangmei Pharmaceutical

Hunan Tianjicaotang Pharmaceutical

Jiangxi Kingstone Unite Pharmaceutical

Shuguang Hospital, Shanghai University of TCM

Hunan Province Directly Affiliated TCM Hospital

First Hospital of Hunan University of Chinese Medicine

Second Xiangya Hospital of Central South University

Second Hospital of Hunan University of Chinese Medicine

Orthopedics of TCM Zhuzhou City

[ Buyer FAQ 07 ]

Frequently Asked Questions from Global Buyers

Practical answers for procurement managers, R&D directors and brand owners evaluating a natural medicine CRO/CDMO partner.

What does a natural medicine CRO like MedGence do?

We provide end-to-end R&D for plant-derived ingredients: active ingredient screening, potency evaluation by origin and season, analytical method establishment, process studies, toxicity, in vitro, animal and clinical studies, natural formulation research, and contract manufacturing of both active ingredients and finished products.

Can one partner take my botanical project from lab research to commercial supply?

Yes. Our own pilot plant and collaborative factories are directly managed by our technical team, so validated study results transfer smoothly into OEM/CDMO production without the knowledge gaps that occur when research and manufacturing are split between vendors.

Which analytical techniques are used to establish quality standards?

Depending on the product, methods include high-performance thin-layer chromatography (HPTLC) identification, high-performance liquid chromatography (HPLC), gas chromatography (GC) and chromatographic fingerprinting — giving your QC team reliable tools for identity, assay and batch consistency.

How is my formula and process know-how protected?

We operate on an entrusted contract research and manufacturing model under non-disclosure. Your product information, formulas and process parameters are not disclosed, preserving your competitive advantage in the market.

Which dosage forms can you develop and manufacture?

Active ingredients can be supplied as concentrated liquids, powders, pastes and volatile oils. Finished products include oral liquids, capsules, softgels, tablets, soluble powders and granules.

Do you support clinical studies for new drug applications?

Yes. We arrange small-group human trials for dietary supplements as well as Phase I, II, III and IV clinical studies to help clients obtain the data required for a new drug application (NDA).

[ Start Your Project ]

Plan Your Next Botanical Ingredient Project

Get our service catalog with study scopes, typical deliverables and available dosage forms — or send your brief directly to our scientific team at [email protected].

Request a Catalog Contact us

Natural Medicine CRO & CDMO for Evidence-Based Botanical Ingredients

Turning Traditional Knowledge into Verifiable Data

Talk to a Scientist About Your Project

Hundreds of Thousands of Research Batches

Built for Three Markets

Confidential by Design

12 Integrated Natural Medicine R&D and Manufacturing Services

Botanical Active Ingredient Screening

Potency Evaluation by Origin, Season & Plant Part

Analytical Method Establishment

Process Study for Active Ingredients

Process Study for Finished Products

Toxicity Studies (LD50, Acute, Chronic, Genotoxicity)

In Vitro Testing

Animal Studies

Clinical Studies (Phase I–IV)

Natural Formulation Research

Contract Manufacturing (OEM) for Active Ingredients

Contract Manufacturing (OEM/CDMO) for Finished Products

From Raw Herb to Registered Product: How Your Project Moves Forward

Screen & Source

Standardize & Analyze

Optimize the Process

Prove Safety & Efficacy

Clinical Validation

Manufacture & Supply

Proven Scale in Natural Medicine Research

Applications & Deliverable Formats for Global Brands

Dietary Supplements & Nutraceuticals

Phytochemical New Drug Development

Cosmetics & Personal Care

Active Ingredient Forms

Finished Dosage Forms

Trusted by Leading Pharmaceutical Groups and TCM Hospitals

Frequently Asked Questions from Global Buyers

What does a natural medicine CRO like MedGence do?

Can one partner take my botanical project from lab research to commercial supply?

Which analytical techniques are used to establish quality standards?

How is my formula and process know-how protected?

Which dosage forms can you develop and manufacture?

Do you support clinical studies for new drug applications?

Plan Your Next Botanical Ingredient Project