Comprehensive Research, Analytical Method Development, Toxicological Validation, and Industrial-Scale Contract Manufacturing for Global Phytopharmaceutical & Nutraceutical Formulations.
Direct contract access to advanced molecular screening, chromatographic analytical profiling, preclinical pharmacology, and comprehensive regulatory dossiers.
Bridging millennia of Traditional Chinese Medicine (TCM) empirical evidence with Western pharmacopeial compliance, quantitative metabolomics, and reproducible bioactivity.
MedGence (Yineng Pharma) operates at the convergence of botanical taxonomy, separation technology, and molecular pharmacology. By transitioning classical TCM formulations into well-characterized botanical drug substances, we decipher complex biological functions into quantifiable chemical markers.
Evidence-Based MedicineWith an active multidisciplinary cadre of over 300 research scientists, we have spearheaded modernized research on 83 classic TCM formulas, engineered 22 innovative natural medicines, achieved 56 hospital preparation registrations, and standardized near 400 single-herb extracts.
300+ Dedicated ScientistsOperating exclusively under non-disclosure entrusted CDMO frameworks, client IP remains hermetically sealed. Proprietary extraction parameters, custom fractional ratios, and proprietary formulation recipes are never commercialized under internal house labels.
100% Client IP ProtectionGlobal pharmaceutical corporations, dietary brand conglomerates, and functional beverage enterprises face escalating scrutiny over raw material consistency, supply continuity, and botanical authenticity.
Botanicals harvested across disparate microclimates exhibit wide variations in secondary metabolite yields. Our comprehensive multi-origin seasonal potency evaluations remove volatility, guaranteeing batch-to-batch standardization.
Tier-1 markets demand rigorous compliance regarding heavy metals, polycyclic aromatic hydrocarbons (PAHs), ethylene oxide (EtO), and pesticide residues. Our protocols meet strict USP, EP, and JP statutory thresholds.
Securing market clearance requires more than pure chemistry; it requires defensible biological proof. We deliver comprehensive toxicological safety dossiers (LD50, Ames test, micronucleus) and validated in vitro / in vivo efficacy files.
Eliminating translational failure between bench-top discovery and multi-ton industrial campaigns. Our integrated pilot facilities and contract manufacturing lines guarantee flawless tech transfer without loss of biological yield.
Harnessing China’s unique geographic diversity, deeply clustered industrial supply chains, and advanced bioprocess engineering infrastructure.
China is home to the world’s most extensive natural habitat diversity for medicinal flora. Direct proximity to indigenous botanical cultivation hubs ensures our materials preserve their full spectrum of secondary bioactive components.
Our collaborative industrial manufacturing centers house high-capacity continuous countercurrent extraction lines, supercritical CO2 equipment, macroporous resin adsorption columns, and low-temperature freeze-drying complexes.
Deploying specialized natural medicine CRO programs in China compresses discovery timelines by over 45% compared to Western clinical research firms, while substantially reducing initial clinical R&D expenditure.
Explore our 12 deeply integrated service modules, built to accompany projects from raw herb discovery through validated manufacturing and clinical certification.
Plants contain alkaloids, polysaccharides, saponins, and flavonoids. Leveraging extensive phytochemistry databases and high-content screening, we identify molecules delivering targeted biological functions with optimal environmental sustainability.
View service detailsBioactive density varies significantly across growing regions, micro-climates, and harvest periods. We quantify secondary metabolite yields across roots, stems, leaves, and flowers to establish competitive procurement blueprints.
View service detailsAnalytical rigor guarantees quality reliability. We formulate validated assay and qualitative identification standards utilizing HPTLC, HPLC-DAD, GC-MS, and multi-wavelength chromatographic fingerprinting for multi-herb formulas.
View service detailsIndustrial scale-up economics define global market viability. Our chemical engineers optimize raw-herb preparation, enzymatic digestion, solvent ratios, resin separation, and spray drying to maximize purity and economic yields.
View service detailsFormulating sensitive botanical extracts into solid or liquid forms frequently leads to degradation or loss of bioavailability. We resolve crystallization, poor solubility, and hygroscopicity to maintain biological activity.
View service detailsDocumented safety profiles are critical prerequisites for health authorities worldwide. We execute rigorous GLP-compliant acute oral toxicity, LD50, 90-day subchronic oral studies, and in vitro Ames bacterial reverse mutation tests.
View service detailsDirect cellular and enzymatic models elucidate complex bioactivity mechanisms. We deploy high-throughput assays for metabolic enzyme inhibition, reactive oxygen species (ROS) neutralization, and anti-inflammatory cellular pathways.
View service detailsPreclinical in vivo rodent models evaluate biological bioavailability, targeted tissue distribution, pharmacodynamics, and specific efficacy endpoints (glycemic regulation, lipid balancing, and neurocognitive protection).
View service detailsComprehensive human trials covering small-cohort dietary supplement efficacy substantiation through full GCP-compliant Phase I–IV clinical study protocols required for Botanical Investigational New Drug (IND/NDA) filings.
View service detailsHarnessing deep classic TCM systemic theory combined with modern pharmacological synergy. We design specialized natural formulations offering superior functional efficacy across immune support, metabolic balance, and skin integrity.
View service detailsCommercialization backed by fully owned pilot facilities and inspected collaborative factories. Bioactive extracts are produced as customized concentrated liquids, crystalline extract powders, pastes, and volatile botanical oils.
Request specificationsTurnkey finished dosage manufacturing operating under pharmaceutical-grade GMP environments. Formats include functional oral liquids, hard gelatin capsules, vegan softgels, direct-compression tablets, soluble powders, and micro-granules.
Request specificationsOvercoming jurisdictional friction. Our regulatory science division aligns technical packages directly with health authority standards across all major target territories.
Preparation of comprehensive New Dietary Ingredient (NDI) notifications and Generally Recognized as Safe (GRAS) affirmation dossiers. Batch documentation complies fully with FDA 21 CFR Part 111 dietary supplement standards.
Assistance in constructing European Food Safety Authority (EFSA) Novel Food dossiers, ensuring compliant residual solvent levels, absence of irradiation, and full alignment with EU Traditional Herbal Medicinal Products Directive (THMPD 2004/24/EC).
Providing Listed Medicine evidence dossiers for the Australian Therapeutic Goods Administration (TGA) as well as Blue Hat dietary filings and Hospital Preparation registrations for China's National Medical Products Administration (NMPA).
Fourteen years of sustained scientific achievement supporting premier medical institutions and multinational pharmaceutical corporations.
Translating active botanical biological functions into distinct, highly bioavailable commercial delivery architectures.
Potency-standardized extracts with verified bioassays for metabolic health, cognitive clarity, immune resilience, and healthy aging. Designed for high shelf-stability and clear label claims.
Purified active fractions and standardized botanical drug substances engineered to satisfy stringent FDA Botanical Drug Guidance thresholds, supported by robust preclinical and clinical data packages.
Water-soluble, clear-dissolution botanical bioactives delivering clinical dermatological performance: tyrosinase inhibition, dermal barrier repair, and advanced anti-pollution antioxidant defense.
The botanical functions sector is moving rapidly beyond crude macerations toward molecularly precise, bio-engineered phyto-therapeutics.
Integrating machine learning algorithms with high-resolution mass spectrometry (HRMS) to predict molecular targets, synergistic multi-compound interactions, and bio-affinity before initiating wet-lab synthesis.
Harnessing enzymatic catalysis and microbial fermentation to convert bulky glycosylated ginsenosides, icariins, and astragalosides into highly bioavailable rare aglycones with improved bioavailability profiles.
Overcoming the poor water solubility of complex polyphenols and terpenes via pharmaceutical-grade phospholipid nano-liposomes, solid lipid nanoparticles (SLNs), and microencapsulated beadlets.
A transparent milestone-driven structure providing procurement and scientific teams with defined deliverables at each development phase.
Identify target compounds delivering the intended biological function and select optimal geographic origins, seasons, and plant organs.
Deliverable: Target & Sourcing ReportEstablish validated analytical methods via HPTLC, HPLC, and GC-MS alongside comprehensive raw material release monographs.
Deliverable: Validated Methods & SpecsDetermine pretreatment parameters, solvent recovery ratios, column purification efficiencies, and optimal drying conditions.
Deliverable: Key Process ParametersConduct in vitro high-content cellular assays, in vivo animal models, acute toxicity (LD50), chronic toxicity, and genotoxicity tests.
Deliverable: Preclinical Data PackageExecute human dietary pilot cohorts or full Phase I–IV clinical studies in compliance with Good Clinical Practice (GCP) guidelines.
Deliverable: Clinical Study DossierSeamless tech transfer to pilot and commercial cGMP OEM/CDMO production with confidential batch release and export documentation.
Deliverable: Commercial C-GMP BatchesOur collaborative research footprint powers China’s premier national pharmaceutical enterprises and tier-3 clinical university hospitals.
China Beijing Tongrentang Group
China Resources Sanjiu Medical
Sunflower Pharmaceutical Group
Livzon Pharmaceutical Group
Dihon Pharmaceutical Group
Golden Throat Holdings Group
Yangtzi River Pharmaceutical
Beihai Gofar Chuanshan Biological
Humanwell Healthcare Group
SCIMYTH Pharmaceutical Group
Shandong Hanfang Pharmaceutical
Luoxin Pharmaceutical Group
Guangdong Zhongsheng Pharma
Brilliance & Abundance Herbal
Apeloa Pharmaceutical
Hunan Heng Chang Pharma
Baotou Traditional Chinese Medicine
Kamp Medicine Co., Ltd.
Guangxi Santo Pharmaceutical
Hunan Kangshou Pharmaceutical
Jiangxi Juwang Pharmaceutical
Beijing Tcmages Pharmaceutical
Guizhou Ruihe Pharmaceutical
Anhui CR Jinchan Pharmaceutical
Kangmei Pharmaceutical Co.
Hunan Tianjicaotang Pharma
Jiangxi Kingstone Unite Pharma
Shuguang Hospital, Shanghai TCM
Hunan Affiliated TCM Hospital
1st Hospital of Hunan TCM Univ.
2nd Xiangya Hospital, CSU
2nd Hospital of Hunan TCM Univ.
The Orthopedics of Traditional Chinese Medicine of Zhuzhou CityDirect technical answers addressing regulatory oversight, intellectual property frameworks, analytical parameters, and batch scale-up.
Accelerate your project pipeline with our standardized research suites, preclinical pharmacology protocols, and commercial OEM batch production.
Whether you require targeted active molecule screening, chromatographic fingerprint establishment, in vivo toxicology files, or multi-ton commercial extract manufacturing under strict non-disclosure, our scientific team is ready to assist.